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  • Title: Treatment of hypothalamic infertility with pulsatile GN-RH administration.
    Author: Turla R, Dordoni D, Falsetti L, Omodei U, Scagliola P.
    Journal: Acta Eur Fertil; 1984; 15(6):445-8. PubMed ID: 6399175.
    Abstract:
    In this study the Authors have obtained an ovulatory response using intravenous Gn-RH treatment in four patients with hypothalamic hypogonadotropic amenorrhea. The Gn-RH was administered in a pulsatile manner with a small portable autoinfusion pump (Autosyringe, Inc., Hooksett). The ovarian follicular maturation, as it appears from the pelvic echography, was perfectly similar to that observed in a spontaneous ovulatory cycle. Endocrine picture by serial determination of gonadotropin; prolactin, estradiol and progesterone concentrations showed hormone values to be in the normal range. During the therapy no complications were observed; at the present time no pregnancy has occurred.
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