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  • Title: Immunohistochemical typing of amyloid on hydroxyethyl-methacrylate-embedded renal biopsies.
    Author: Donini U, Casanova S, Dal Bosco F, Linke RP.
    Journal: Appl Pathol; 1984; 2(6):299-307. PubMed ID: 6400463.
    Abstract:
    Hydroxyethyl-methacrylate (GMA)-embedded renal biopsies containing amyloid were tested by the indirect immunoperoxidase method with antibodies against the following purified amyloid fibril proteins: AA, three different A lambda preparations, Ak and AF. The anti-AA reagent was monoclonal (mc13), all the others were polyclonal. In four biopsies from cases with generalized amyloidosis, two were found to be of the AA and two of the A lambda type. Two control cases of membranous glomerulonephritis showed only a marginal reaction with anti-A lambda. These results demonstrate that GMA-embedded tissue sections are suitable for immunohistochemical classification of amyloid diseases, because proteinaceous antigenic determinants of amyloid fibril are preserved.
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