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  • Title: Effects of leucine-enkephalin on hypothalamic-pituitary-thyroid axis in rats.
    Author: Mitsuma T, Nogimori T.
    Journal: Life Sci; 1983 Jan 17; 32(3):241-8. PubMed ID: 6401835.
    Abstract:
    Basal thyrotropin (TSH) levels in plasma and the TSH response to thyrotropin-releasing hormone (TRH) were inhibited after Leucine-enkephalin (L-EK) administration iv in rats. TRH and TSH responses to cold were inhibited after L-EK administration. In the L-DOPA, haloperidol or 5-hydoxytryptophan-treated rats, the inhibitory effect of L-EK on TSH release was restored. Findings suggested that L-EK acted both the hypothalamus and pituitary. Its inhibitory effects on TRH and TSH release at least partially mediated by interaction with amines in the central nervous system.
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