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  • Title: Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.
    Author: Dunzendorfer U, Relyea NM, Kleinert E, Balis ME, Whitmore WF.
    Journal: Oncology; 1983; 40(1):57-62. PubMed ID: 6401860.
    Abstract:
    Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect. The combination of DFMO with MGBG was not only more effective but no more toxic than MGBG alone. Combination of MGBG with 9-B-D-arabinofuranosyladenine, an indirect effector of SAMDC, failed to increase therapeutic effectiveness of MGBG.
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