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  • Title: Structure determination of the major asparagine-linked sugar chain of human factor VIII--von Willebrand factor.
    Author: Debeire P, Montreuil J, Samor B, Mazurier C, Goudemand M, van Halbeek H, Vliegenthart JF.
    Journal: FEBS Lett; 1983 Jan 10; 151(1):22-6. PubMed ID: 6402380.
    Abstract:
    N-glycosidically-linked glycans released by hydrazinolysis of human factor VIII/von Willebrand factor (FVIII/vWf) were separated by high-voltage electrophoresis. Five fractions were obtained, one of them representing 60% of the total amount of the N-glycosidically-linked glycans of FVIII/vWf. On the basis of the carbohydrate composition, methylation analysis and 500 MHz 1H-NMR spectroscopy, we describe the primary structure of this major glycan which is of the monosialylated and monofucosylated biantennary N-acetyllactosaminic type.
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