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  • Title: Freeze-fracture localization of filipin-cholesterol complexes in the plasma membrane of Trypanosoma cruzi.
    Author: Souto-Padrón T, de Souza W.
    Journal: J Parasitol; 1983 Feb; 69(1):129-37. PubMed ID: 6402578.
    Abstract:
    The polyene antibiotic filipin was used as a probe for the detection of cholesterol on the P and E faces of the cell body and the flagellar membranes of epimastigotes of Trypanosoma cruzi. When glutaraldehyde-fixed cells were treated with filipin the filipin-cholesterol complexes were homogenously distributed throughout the parasite's plasma membrane. In some cells, mainly on their P faces, such complexes were arranged linearly forming parallel bands with a distance between the bands similar to that existent between the subpellicular microtubules that are attached to the plasma membrane. Filipin-cholesterol complexes were more abundant in the flagellar membrane than in the membrane that enclosed the cell body. No filipin-cholesterol complexes were seen in the membrane of intracellular organelles. Treatment of living epimastigotes with filipin-induced aggregation of cholesterol and intramembranous particles.
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