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  • Title: Thyroid failure and protirelin (thyrotropin-releasing hormone) test abnormalities in depressed outpatients.
    Author: Sternbach HA, Gold MS, Pottash AC, Extein I.
    Journal: JAMA; 1983 Mar 25; 249(12):1618-20. PubMed ID: 6402617.
    Abstract:
    Forty-four consecutive outpatients referred to a psychiatric hospital for evaluation of depression and anergia were assessed by means of the protirelin (thyrotropin-releasing hormone) test. Nineteen patients (43%) had a blunted thyrotropin (TSH) response to protirelin, while six patients (13.5%) had augmented TSH responses indicating some degree of hypothyroidism. One patient had a low thyroxine level, while three patients had elevated basal TSH levels. Five of the six patients with augmented TSH responses were found to have antithyroid antibodies. These results suggest that a majority of depressed outpatients have abnormalities on the protirelin test and that the TSH response to protirelin is useful in both confirming a diagnosis of major depression and assessing thyroid status.
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