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  • Title: Further studies on sister-chromatid exchange frequency in users of hormonal contraceptives.
    Author: Murthy PB, Prema K.
    Journal: Mutat Res; 1983 Mar; 119(3):351-4. PubMed ID: 6402698.
    Abstract:
    Women using an estrogen-progestogen combination contraceptive exhibited an increased frequency of sister-chromatid exchange (SCE), supporting our previous observation. These elevated SCE frequencies tended to decline 3 months after the discontinuation of the pill. Women using a progestogen injectable contraceptive, on the other hand, had unaltered SCE rates. The analysis, in vitro; of mitomycin-C-induced SCE frequencies in women using either the combination or the progestogen injectable contraceptives showed significantly higher rates of induced SCE.
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