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  • Title: [Genetic differences in mice in the sensitivity to the immunodepressive action of alkylating agents].
    Author: Kim NI, Telegin LIu, Pevnitskiĭ LA.
    Journal: Biull Eksp Biol Med; 1983 Apr; 95(4):79-81. PubMed ID: 6403076.
    Abstract:
    The immunodepressant action of cyclophosphamide, thiophosphamide and sarcolysine was examined in experimental primary immune response in mice of different lines immunized with sheep red blood cells. DBA/2 and C3H/Sn mice were marked by the highest sensitivity to the immunodepressant action of the alkylating agents. BALB/c mice were relatively resistant to the immunodepressant action. Possible reasons for the interspecific differences found are discussed.
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