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  • Title: Contraception with levonorgestrel, 0.15 mg, and ethinyl estradiol, 0.03 mg. Clinical studies in Latin America.
    Author: Moggia AV.
    Journal: J Reprod Med; 1983 Jan; 28(1 Suppl):77-80. PubMed ID: 6403704.
    Abstract:
    Levonorgestrel, 0.15 mg, and ethinyl estradiol, 0.03 mg, an ultra-low-dose oral contraceptive product, was studied in Latin America. In total, 1,206 sexually active, fertile women in their reproductive years were followed through 9,736 cycles. Only one of eight pregnancies was attributed to failure of the medication, resulting in a corrected Pearl index of 0.13. Very good cycle regulation was achieved, with an acceptably low rate of intermenstrual bleeding. The medication was discontinued for medical reasons in only 5% of the patients. Apart from a mild case of thrombophlebitis, there were no major side effects. These studies show that this combination oral contraceptive provides effective contraception with a very low incidence of side effects. 0.15 mg levonorgestrel and 0.03 mg ethinyl estradiol, an ultra-low-dose oral contraceptive (OC) was studied in Latin America. In total, 1206 sexually active, fertile women in their reproductive years were followed through 9736 cycles. Only 1 of 8 pregnancies was attributed to failure of the medication, resulting in a corrected Pearl Index of 0.13. Very good cycle regulation was achieved, with an acceptably low rate of intermenstrual bleeding. The medication was discontinued for medical reasons in only 5% of the patients. Apart from a mild case of thrombophlebitis, there were no major side effects. These studies show that this combination OC provides effective contraception with a very low incidence of side effects.
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