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  • Title: Bone cell differentiation and growth factors.
    Author: Urist MR, DeLange RJ, Finerman GA.
    Journal: Science; 1983 May 13; 220(4598):680-6. PubMed ID: 6403986.
    Abstract:
    Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.
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