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  • Title: Sweat tests to diagnose cystic fibrosis in adults.
    Author: Hodson ME, Beldon I, Power R, Duncan FR, Bamber M, Batten JC.
    Journal: Br Med J (Clin Res Ed); 1983 Apr 30; 286(6375):1381-3. PubMed ID: 6404469.
    Abstract:
    Twenty five patients with cystic fibrosis and 25 controls were studied to define a sweat sodium concentration in adults that could be taken as diagnostic of cystic fibrosis. Some of the controls had a sweat sodium concentration of over 50 mmol(mEq)/l, and thus cystic fibrosis should be diagnosed in an adult only when two measurements of sweat sodium concentration are above 70 mmol/l. In cases in which the sweat sodium concentration was borderline a suppression test using fludrocortisone improved the accuracy of diagnosis; this test entails recording the lowest concentration reached after administration of the drug. A scatter diagram of the baseline sweat sodium concentrations plotted against the lowest concentration attained after suppression with fludrocortisone may aid the diagnosis further.
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