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  • Title: Pharmacokinetic study with synthetic salmon calcitonin (Sandoz).
    Author: Beveridge T, Niederer W, Nüesch E, Petrin A.
    Journal: Z Gastroenterol Verh; 1976; (10):12-5. PubMed ID: 64046.
    Abstract:
    18 patients randomly divided into 3 groups of six each received 35 mug (140 M.R.C. Units) of synthetic salmon calcitonin intravenously, intramuscularly or subcutaneously. Plasma and urin concentrations were determined using the radioimmunoassay method. There was a rapid distribution phase of ca. 12 minutes after intravenous injection then an elimination half-life of 1.1 hours. The volume of distribution was 11 litres. The invasion half-life after intramuscular and subcutaneous administration was 12 and 11 minutes respectively and the elimination half-lives 1 and 1.5 hours, respectively. The bioavailability of the intramuscular and subcutaneous forms was found to be 66 and 71% respectively when areas under their plasma concentration/time curves were compared with the intravenous area.
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