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  • Title: The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma.
    Author: Scisłowski PW, Słominski A.
    Journal: Neoplasma; 1983; 30(2):239-43. PubMed ID: 6405289.
    Abstract:
    The activities of NADP-linked dehydrogenases in the cytosol of amelanotic, black melanotic and brown melanotic hamster melanoma are presented. It has been shown that the tyrosine to DOPA hydroxylation is stimulated by the NADPH produced in the reaction catalyzed by either isocitrate dehydrogenase or glucose-6-phosphate dehydrogenase. The significance of NADPH in the hydroxylation of tyrosine to dopa in hamster melanoma is discussed.
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