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  • Title: Effect of melatonin-free pineal extract on prolactin in castrated and thyrotropin releasing hormone-stimulated rats.
    Author: Damian E, Ianăş O, Bădescu I.
    Journal: Endocrinologie; 1983; 21(1):23-7. PubMed ID: 6405477.
    Abstract:
    Administration of a melatonin-free pineal extract to the rat induced the following effects on prolactin: a) under basal conditions, after 4 hrs from a single injection or after 3 days of treatment, there was a decrease of 34% and 28% respectively, in serum prolactin, with no change in the pituitary content of this hormone; b) when prolactin was stimulated by castration the decrease of the serum level of this hormone (-37%) was accompanied by a decrease in its pituitary content (-33%) and concentration (-35%); c) under conditions of exogenous TRH stimulation the decrease in serum prolactin (-26%) was accompanied by a decrease in pituitary prolactin content (-27%) and concentration (-21%), the latter two without statistical significance. The role of the pineal gland on prolactin is discussed.
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