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  • Title: A comparative study of bupropion and amitriptyline in depressed outpatients.
    Author: Mendels J, Amin MM, Chouinard G, Cooper AJ, Miles JE, Remick RA, Saxena B, Secunda SK, Singh AN.
    Journal: J Clin Psychiatry; 1983 May; 44(5 Pt 2):118-20. PubMed ID: 6406439.
    Abstract:
    A double-blind controlled trial comparing a standard antidepressant drug, amitriptyline, with a new compound, bupropion, was conducted at six centers. There was a placebo washout, after which patients were assigned in a randomized fashion to one of the two treatments. No significant difference was found in therapeutic response to the two drugs after 4 weeks of treatment. Anticholinergic and cardiovascular side effects were less common in the bupropion-treated patients.
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