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  • Title: Safety and efficacy of bupropion in elderly patients: preliminary observations.
    Author: Kane JM, Cole K, Sarantakos S, Howard A, Borenstein M.
    Journal: J Clin Psychiatry; 1983 May; 44(5 Pt 2):134-6. PubMed ID: 6406442.
    Abstract:
    The efficacy and safety of bupropion, an atypical antidepressant, were assessed in depressed patients aged 55 and above. Data were analyzed for 38 patients who completed 4 weeks of double-blind treatment with bupropion in maximum doses of 150 or 450 mg/day; imipramine, up to 200 mg/day; or placebo. Preliminary results suggest that bupropion does have antidepressant activity and is well tolerated in this population. A particular advantage is suggested in terms of cardiovascular side effects.
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