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  • Title: Circannual variations in serum concentrations of pituitary, thyroid, parathyroid, gonadal and adrenal hormones in male laboratory rats.
    Author: Wong CC, Döhler KD, Atkinson MJ, Geerlings H, Hesch RD, von zur Mühlen A.
    Journal: J Endocrinol; 1983 May; 97(2):179-85. PubMed ID: 6406632.
    Abstract:
    Seasonal effects were studied on basal levels of hormones in the serum of adult male Sprague-Dawley rats, which were born and raised under rigorously controlled laboratory conditions. Groups of 90-day-old rats were killed at monthly intervals by rapid decapitation. Significant fluctuations were observed throughout the observation period of 19 months in serum levels of TSH, prolactin, androgens, tri-iodothyronine and LH. Minor fluctuations were observed in serum levels of FSH, corticosterone, parathyroid hormone and thyroxine. The results indicate that male laboratory rats exhibit circannual and semi-annual fluctuations in serum levels of several hormones even though the animals were born, raised and maintained in constant laboratory conditions.
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