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  • Title: Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene.
    Author: Johnson DH, Friedman TB.
    Journal: Proc Natl Acad Sci U S A; 1983 May; 80(10):2990-4. PubMed ID: 6407004.
    Abstract:
    Mutants of Drosophila melanogaster selected for resistance to purine killing are deficient in adenine phosphoribosyltransferase (APRT; E.C. 2.4.2.7) activity. Genetic mapping and complementation analysis demonstrate that purine resistance, deficiency of APRT activity, and differences in the isoelectric point of APRT result from alterations at a single locus, Aprt (map position, 3:3.03). The level of APRT activity shows gene dose dependence in Aprt heterozygotes and in flies that are haploid for different Aprt alleles. Drosophila APRT is a dimer composed of apparently identical 23,000-dalton subunits. These results suggest that Aprt contains the structural gene for APRT.
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