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  • Title: Memory retention in old rats: improvement by orotic acid.
    Author: Rüthrich HL, Wetzel W, Matthies H.
    Journal: Psychopharmacology (Berl); 1983; 79(4):348-51. PubMed ID: 6407051.
    Abstract:
    The effect of methylglucamine orotate (MGO) on learning and memory was investigated in 24-month-old rats using brightness discrimination in a Y-chamber and active avoidance in a shuttle box. In both learning procedures, an improvement of memory retention following 5-day MGO treatment (225 mg/kg per day) was observed. The retention of untreated old animals was significantly lower compared to 8-week-old rats. MGO treatment resulted in a significant improvement of retention in old rats, which nearly compensated for their memory deficit.
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