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  • Title: [Standardization of the nutrient medium for determining the biological activity of a number of antibiotics by the diffusion-in-agar method].
    Author: Bershteĕin EM, Vasil'eva NG, Poliak MS.
    Journal: Antibiotiki; 1983 Apr; 28(4):250-4. PubMed ID: 6407390.
    Abstract:
    The possibility of using 2 variants of a unified nutrient medium containing no Hottinger's broth for determination of the biological activity of a large number of antibacterial antibiotics was shown. The medium provided satisfactory reproducibility of the results. It contained yeast extract as a source of nitrogen. The medium was selected with the method of the fractional factor experiment. Clear inhibition growth zones and the slope of the dose-response curve were used as the criteria for estimation of the optimal medium. The described nutrient medium allowed a 2-time increase in the sensitivity of the method used for determination of the biological activity of neomycin, monomycin, streptomycin, oxytetracycline, chlortetracycline and erythromycin.
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