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  • Title: Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea.
    Author: Menon V, Edwards RL, Lynch SS, Butt WR.
    Journal: Br J Obstet Gynaecol; 1983 Jun; 90(6):539-42. PubMed ID: 6407517.
    Abstract:
    The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome). After an initial phase of stimulation, there was a uniform and sustained suppression of gonadotrophin concentrations in all the patients during the 20-24 days of treatment, presumably due to down-regulation of the pituitary receptors. One patient ovulated after stopping treatment.
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