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  • Title: [Inducing effects of bis-hydroxyethylthio-1,10-decane (tiadenol) on hepatic microsomal enzymes of the rat].
    Author: Mounie J, Goudonnet H, Bereksi-Reguig K, Escousse A, Truchot R.
    Journal: J Pharmacol; 1983; 14(2):171-82. PubMed ID: 6408317.
    Abstract:
    1. Male Wistar rats were treated with tiadenol, 200 mg/kg/ p.o. daily for 7 days. 2. The administration of tiadenol markedly increased the activity of bilirubin glucuronosyl transferase in hepatic microsomes. Cytochrome P 450 levels and ethoxycoumarin deethylase activity were more slightly increased. 3. Electrophoresis of microsomal proteins showed the induction of a protein with a molecular weight of about 72,000. 4. Tiadenol alone only slightly affected the fatty acid composition of microsomal lecithins and cephalins. When given with phenobarbital, however, tiadenol modified the phenobarbital-induced changes in the fatty acid composition of microsomal lipids.
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