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  • Title: Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs.
    Author: Sircar JC, Schwender CF, Johnson EA.
    Journal: Prostaglandins; 1983 Mar; 25(3):393-6. PubMed ID: 6408711.
    Abstract:
    Eighteen known nonsteroidal antiinflammatory drugs (NSAID) were tested for their action against soybean lipoxygenase (E.C.1.13.11.12) using linoleic acid as substrate. It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam. Drugs with intermediate potency were meclofenamic acid, phenylbutazone and benoxaprofen. Other drugs such as ibuprofen and zomepirac were only weakly active in the test.
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