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  • Title: Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes.
    Author: Abe K, Matsuura N, Fukushima N, Nohara Y, Fujita H, Fujieda K, Kato T.
    Journal: Tohoku J Exp Med; 1983 May; 140(1):29-34. PubMed ID: 6408763.
    Abstract:
    The basal and TRH-induced prolactin (PRL) and TSH secretions were examined in 14 children aged 4 to 13 years with newly diagnosed insulin dependent diabetes (IDD) within three weeks after diagnosis. Basal PRL levels did not differ from the values of control. In response to TRH, 6 out of 14 patients showed an exaggerated PRL response and 8 a normal PRL response. The basal and TRH-induced TSH secretions were normal, while plasma triiodothyronine (T3) and thyroxine (T4) concentrations were significantly (p less than 0.001, p less than 0.02) lower in patients than in controls. These findings suggest that a significant proportion of children with newly diagnosed IDD has an exaggerated PRL response to TRH, and TSH secretion remains unchanged despite significant decreases of circulating thyroid hormone levels.
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