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  • Title: A randomized, double-blind, parallel group comparison of disopyramide phosphate and quinidine in patients with cardiac arrhythmias.
    Author: Arif M, Laidlaw JC, Oshrain C, Willis PW, Nissen CH, McDermott DJ, Smith WS, Karim A, Wilson RR.
    Journal: Angiology; 1983 Jun; 34(6):393-400. PubMed ID: 6408949.
    Abstract:
    This report summarizes the results of a randomized, double-blind, parallel group, multicenter study which compared the antiarrhythmic activity and safety of oral disopyramide phosphate and oral quinidine sulfate. A total of 124 outpatients, whose pretreatment rates of ventricular and/or supraventricular arrhythmias were documented by ambulatory ECG recordings, were randomly assigned to receive either oral disopyramide or oral quinidine for the eight-week course of the study. Every two weeks, ten-hour ambulatory ECG recordings were obtained from each patient and blood was drawn to determine serum concentrations of assigned drug.
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