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  • Title: [Evaluation of chemotherapy of breast cancer (2). Clinical evaluation of the blood and tissue concentrations of FT-207 following intrarectal administration].
    Author: Hiraide H, Mimura K, Kawano M, Hatsuse K, Kadota T, Kurokawa T, Tamaki K, Kanabe S, Mizoguchi O, Terashima H, Iwasa H.
    Journal: Gan To Kagaku Ryoho; 1983 Apr; 10(4 Pt 1):992-6. PubMed ID: 6408994.
    Abstract:
    In order to examine the transfer of antitumor drug in breast cancer after administration of FT-207 suppository, FT and 5-FU concentrations in blood, tumor tissues, normal tissues and axillary lymph nodes were determined respectively. FT and 5-FU concentrations in tumor tissues were higher than those in normal tissues or lymph nodes in every cases, and there was a significant difference between FT and 5-FU concentration in blood and tumor tissues. Blood levels of FT and 5-FU remained quite constant at 16 and 20 hours after administration, respectively. Accordingly, it was suggested that the administration of FT-207 suppository to breast cancer was very effective as an adjuvant chemotherapy.
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