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  • Title: Opiate peptides control growth hormone through a cholinergic mechanism in man.
    Author: Delitala G, Grossman A, Besser GM.
    Journal: Clin Endocrinol (Oxf); 1983 Apr; 18(4):401-5. PubMed ID: 6409456.
    Abstract:
    Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man.
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