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  • Title: [Buschke's scleredema and monoclonal dysglobulinemia: apropos of 3 cases].
    Author: Clerici T, Faure M, Chouvet B, Perrot H, Hermier C.
    Journal: Dermatologica; 1983; 166(5):240-6. PubMed ID: 6409682.
    Abstract:
    A monoclonal gammopathy was observed in 3 adult patients with long-term and widespread scleredema (Buschke's disease). There was no evidence of multiple myeloma in any patient. The monoclonal immunoglobulin was in every case of the IgG-kappa type. Bence Jones proteinuria was noted in 1 case (kappa). Deposition of monoclonal IgG-kappa in the skin was not detected by immunofluorescence microscopy. These findings and previous reports of 5 cases suggest that diffuse scleredema may be frequently associated with paraproteinemia, but the role of monoclonal immunoglobulins in the pathogenesis of the disease remains to be clarified.
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