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  • Title: Stimulation of prolactin release by angiotensin II in superfused rat anterior pituitary cell aggregates.
    Author: Schramme C, Denef C.
    Journal: Neuroendocrinology; 1983 Jun; 36(6):483-5. PubMed ID: 6410299.
    Abstract:
    Superfusion of rat anterior pituitary cell aggregates with 10-min pulses of 0.1-10 nM angiotensin II (AII) resulted in a prompt and concentration-dependent rise of PRL release. The effect could be blocked by saralasin, an AII receptor antagonist. The response to AII, but not that to TRH, was rapidly desensitized: a 10 nM AII pulse caused an 80% depression of the response to a subsequent 10 nM pulse given 50 min later. The data provide a possible functional significance for the renin-angiotensin system recently demonstrated in the anterior pituitary.
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