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  • Title: HLA phenotypes and idiopathic nephrotic syndrome in children.
    Author: Ruder H, Schärer K, Lenhard V, Wingen AM, Opelz G.
    Journal: Proc Eur Dial Transplant Assoc; 1983; 19():602-6. PubMed ID: 6410384.
    Abstract:
    Ninety-four children with idiopathic nephrotic syndrome (17 steroid-resistant with a histological diagnosis of a focal segmental glomerulosclerosis) were typed for HLA-A, B and DR antigens. The patients showed a significant increase of DR7 (58% vs 18%, p less than 0.0001) and of B8-DR3 (27% vs 5%, p less than 0.05). Combination of both markers (DR7 and B8-DR3) was observed in 14 per cent of patients but in none of the controls (relative risk 15.2). Patients with B8-DR3 and DR7 had a more severe course of INS.
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