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  • Title: Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate.
    Author: Sage MR, Wilcox J, Evill CA, Benness GT.
    Journal: AJNR Am J Neuroradiol; 1983; 4(4):893-5. PubMed ID: 6410875.
    Abstract:
    Using a canine model, the effect of intracarotid injections of the ionic contrast medium methylglucamine iothalamate was compared with that of the nonionic contrast medium iopamidol of similar iodine concentration (280 mg 1/ml). The degree and distribution of blood-brain barrier disruption was assessed using Evans blue stain as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. In all studies with methylglucamine iothalamate, Evans blue staining was demonstrated, and CT enhancement demonstrated a significant mean difference (p less than 0.01) between the control and injected hemispheres. The absence of blood-brain barrier disruption with iopamidol is probably related to its lower osmolality (570 mosmol/kg) compared with methylglucamine iothalamate (1,424 mosmol/kg) and the absence of any cation.
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