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  • Title: Lithium interferes with reserpine-induced dopamine depletion.
    Author: Reches A, Hassan MN, Jackson V, Fahn S.
    Journal: Ann Neurol; 1983 Jun; 13(6):671-3. PubMed ID: 6410976.
    Abstract:
    Long-term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia. In rats, prophylactic lithium administration inhibits reserpine-induced dopamine depletion in the brain. These data indicate that lithium may limit the therapeutic efficacy of reserpine in tardive dyskinesia.
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