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  • Title: Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
    Author: Falck JR, Manna S, Moltz J, Chacos N, Capdevila J.
    Journal: Biochem Biophys Res Commun; 1983 Jul 29; 114(2):743-9. PubMed ID: 6411091.
    Abstract:
    Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.
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