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  • Title: [Responses of isolated hepatic artery segments to barium in the presence of a flavonoid (4-methylesculetin), indomethacin and acetylsalicylate].
    Author: Bettini V, Gamba G, Legrenzi E, Mayellaro F, Santoni G.
    Journal: Boll Soc Ital Biol Sper; 1983 May 30; 59(5):674-8. PubMed ID: 6411101.
    Abstract:
    The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) inhibits the Ba++ induced contraction in smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and Ba++ induced contraction of isolated hepatic artery strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN suppressed the depressive effect of 4-Me on the Ba++ dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release smooth muscle.
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