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  • Title: Acute nonlymphocytic leukemia following bladder instillations with thiotepa.
    Author: Easton DJ, Poon MA.
    Journal: Can Med Assoc J; 1983 Sep 15; 129(6):578-9. PubMed ID: 6411320.
    Abstract:
    A case of therapy-related leukemia is described. Other cases of acute nonlymphocytic leukemia have been associated with the intramuscular administration of thiotepa (an alkylating agent), but this patient received only intravesical instillations of the drug. The interval between the start of chemotherapy and the onset of leukemia was 56 months.
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