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  • Title: Regulation of plasminogen-activator in mastocytoma cells by lymphokines.
    Author: Kramer M, Woodbury RG, Schirrmacher V, Robinson P.
    Journal: Immunobiology; 1983 Jul; 165(1):107-12. PubMed ID: 6411606.
    Abstract:
    Culture supernatants from mitogen-stimulated splenocytes were found to stimulate protease production in P815Y mastocytoma cells. Such supernatants increased cell-associated plasminogen activator levels in a dose-dependent fashion, and under serum-free conditions. In contrast to peritoneal exudate cells, tumor-cell plasminogen activator was not enhanced by the mitogen ConA alone. The tumor cell line P815Y may, thus, be used as a homogeneous cell source for the quantitation of lymphocyte factors which activate or inhibit plasminogen activator activity.
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