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  • Title: [Changes in the membrane fluidity of human neutrophilic granulocytes under the effect of a chemoattractant (FMLP) and of echo virus, type 9, A. Barty strain].
    Author: Bültmann BD, Melzner I, Haferkamp O, Gruler H.
    Journal: Acta Histochem Suppl; 1983; 28():209-11. PubMed ID: 6412297.
    Abstract:
    Preincubation of human polymorphonuclear leucocytes (PMNs) with different concentrations of Echo virus, type 9, strain A. Barty results in viral dose- and time-dependent inhibition of chemotactic cellular response to chemoattractant (N-formylmethionylleucylphenylalanine = FMLP). In the present experiments, by means of biophysical methods using excimer forming lipids (pyrendecanoic acid) the influence of FMLP and Echo 9 virus on membrane fluidity of PMNs was investigated. It is shown that the increase of membrane fluidity elicited by FMLP is reduced by the virus in a dose dependent manner. These results indicate virus-induced disturbance of molecular architecture and failure of natural signal processing of PMN-membranes. This biophysical method, therefore, can be used as a functional histochemical method to demonstrate functional defects in membranes of living cells.
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