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  • Title: [Is valproic acid teratogenic?].
    Author: Robert E, Robert JM, Lapras C.
    Journal: Rev Neurol (Paris); 1983; 139(6-7):445-7. PubMed ID: 6412342.
    Abstract:
    In more than 7 000 cases of neonatal malformations processed up to 1982 in a regional computer register 71 infants had been born from epileptic mothers. A significantly higher than expected number of spina bifida aperta were observed in this group, related to the administration to the mother of the anti-epileptic agent valproic acid. A pathogenic hypothesis and a possible preventive procedure for this type of malformation are discussed.
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