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  • Title: [Autoradiographic studies on the protective effect of mesna in the urinary bladder mucosa of the rat during administration of cyclophosphamide (preliminary communication)].
    Author: Kunze E, Köhnecke B, Engelhardt W, Brock N, Pohl J.
    Journal: Arzneimittelforschung; 1983; 33(6):853-4. PubMed ID: 6412725.
    Abstract:
    Cyclophosphamide (100 mg/kg i.p.) produces severe bladder lesions in rats and induces an intense regeneration of the urothelium which can be followed up by 3H-thymidine incorporation. Simultaneously administered mesna (100 mg/kg i.v.) prevents these bladder lesions and no increased regeneration with 3H-thymidine incorporation can be observed.
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