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  • Title: [Ascending and descending projections of posterior hypothalamus neurons immunoreactive to serotonin after administration of 5-hydroxytryptophan in cats].
    Author: Sakai K, Salvert D, Kitahama K, Kimura H, Maeda T, Jouvet M.
    Journal: C R Seances Acad Sci III; 1983; 296(21):1013-8. PubMed ID: 6413004.
    Abstract:
    Through combined retrograde labeling with HRP and serotonin immunohistochemistry, we have demonstrated that ventral and caudal hypothalamic neurons, both non-immunoreactive and immunoreactive to serotonin after administration of 5-hydroxytryptophane, give rise to direct ascending projections to the entire cerebral cortex as well as direct descending projections to the nucleus locus coeruleus alpha in the pontine tegmentum. A retrograde double labeling method with fluorescent dyes further suggested that the population of ascending hypothalamic neurons is different from that of descending ones.
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