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  • Title: Rapid identification of correctly located intracerebroventricular cannula in the rat.
    Author: Heyes MP, Garnett S, Coates G.
    Journal: J Neurosci Methods; 1983 Aug; 8(4):381-4. PubMed ID: 6413786.
    Abstract:
    We describe a radiographic technique to identify a correctly located cannula in the ventricular system of the rat brain during life. A suspension of thorium dioxide was infused into the left lateral ventricle through a cannula placed in the brain under stereotaxic guidance. Correctly located injections were identified by the presence of a distinct thorium shadow on lateral X-ray of the in situ brain. When 6-hydroxydopamine was co-injected with thorium the resultant depletion of striatal dopamine and the changes in a conditioned avoidance responses were correlated with the degree of spreading of thorium through the ventricular system.
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