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  • Title: Effect of alkaline glutaraldehyde on hepatitis B virus antigens.
    Author: Adler-Storthz K, Sehulster LM, Dreesman GR, Hollinger FB, Melnick JL.
    Journal: Eur J Clin Microbiol; 1983 Aug; 2(4):316-20. PubMed ID: 6414809.
    Abstract:
    The potential of alkaline 2% glutaraldehyde solutions, with and without surface active agents, to alter the antigenicity of hepatitis B virus (HBV) was analyzed and compared to the antigenic alternation capacities of 0.525% sodium hypochlorite and 2.02% formaldehyde solutions. After treatment of a hepatitis B surface antigen-positive plasma at room temperature for 10 min, there was a 51-67% reduction in surface antigen level and a 90-94% decrease in hepatitis B core antigenicity. Glutaraldehyde is proposed as an alternative to the more noxious hypochlorite and formaldehyde solutions for disinfection of HBV-contaminated articles.
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