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  • Title: Swainsonine affects the processing of glycoproteins in vivo.
    Author: Abraham DJ, Sidebothom R, Winchester BG, Dorling PR, Dell A.
    Journal: FEBS Lett; 1983 Oct 31; 163(1):110-3. PubMed ID: 6414843.
    Abstract:
    Rats, sheep and guinea pigs treated with swainsonine excrete 'high mannose' oligosaccharides in urine. The major rat and guinea pig oligosaccharide is (Man)5GlcNAc, whereas sheep excrete a mixture of oligosaccharides of composition (Man)2-5GlcNAc2 and (Man)3-5GlcNAc. The presence of these oligosaccharides suggests that Golgi alpha-D-mannosidase II as well as lysosomal alpha-D-mannosidase is inhibited by swainsonine resulting in storage of abnormally processed asparagine-linked glycans from glycoproteins. Altered glycoprotein processing appears to have little effect on the health of the intoxicated animal, but the accompanying lysosomal storage produces a disease state.
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