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  • Title: Difference between actions of high PCO2 and low [HCO-3] on neurons in the rat medullary chemosensitive areas in vitro.
    Author: Fukuda Y.
    Journal: Pflugers Arch; 1983 Sep; 398(4):324-30. PubMed ID: 6415612.
    Abstract:
    To evaluate the contribution of extracellular fluid (ECF) pH in stimulating the ventral medullary chemosensors, effects on neuronal activities of changing ECF PCO2 and/or [HCO-3] were studied in tissue slices taken from the medulla oblongata of the rat. In many cases changes in neuronal discharges produced by a high PCO2-normal [HCO-3] solution differed from those produced by a low [HCO-3] normal PCO2 solution although the ECF pH was reduced to the same degree (from 7.40 to about 7.15). Only 9 of a total of 76 neurons showed an increase in discharge in response to both acid solutions. Neuronal activation due to high PCO2 was augmented when the ECF pH was returned to a normal value (7.40) by simultaneous increase in [HCO-3]. High PCO2-high [HCO-3] solution (pH 7.40) increased the activity of many neurons which were either inhibited or uninfluenced by high PCO2-normal [HCO-3] (pH 7.15). Neuronal activation due to low [HCO-3] was partially suppressed by compensating for the pH reduction with a concomitant decrease in PCO2. The results suggest that CO2 and HCO-3 independently influence the activity of neurons. Possible roles of ECF H+, CO2 and HCO-3 in activating the ventral medullary chemosensitive structures are discussed.
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