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  • Title: [Activity of NADPH-dependent monooxygenase hydroxylating system of rat liver under the effect of tetramethylthiuramdisulfide].
    Author: Leonenko OB, Kuz'minskaia UA.
    Journal: Ukr Biokhim Zh (1978); 1983; 55(5):574-6. PubMed ID: 6415882.
    Abstract:
    Changes in the activity of a NADPH-dependent monooxygenase system of the rat liver are studied under the effect of tetramethylthiuramdisulphide. Under these conditions aniline hydroxylation is shown to be inhibited to a higher extent than amidopyrine demethylation. Besides a decrease in the level of cytochrome P-450, the central component of the microsomal system of hydroxylation, there appears cytochrome P-420--an inactivated form of cytochrome P-450.
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