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  • Title: Experimental urinary tract infection in rabbits by a group D Streptococcus sp.: a study of serum immunoglobulin classes by enzyme-linked immunosorbent assay.
    Author: Desnottes JF, Fortier B, Bensman A, Ave-Virat A.
    Journal: Ann Microbiol (Paris); 1983; 134A(3):351-8. PubMed ID: 6416123.
    Abstract:
    After induction of pyelonephritis and cystitis in rabbits by a group D streptococcus, the authors measured the specific serum antibody response in the three major immunoglobulin classes. The enzyme-linked immunosorbent assay was performed using group D streptococcal antigen extracted by phenol. Before experimentation, all rabbits had low IgM, IgG and IgA titres against group D streptococcal antigen. A marked increase in IgM antibodies was detected during the first month of experimental pyelonephritis. A poor IgM antibody response was observed in rabbits with cystitis. During the three months of experimentation, a significant difference in mean IgG levels was observed between rabbits with pyelonephritis and those with cystitis.
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