These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.
    Author: Burrows PD, Beck-Engeser GB, Wabl MR.
    Journal: Nature; ; 306(5940):243-6. PubMed ID: 6417542.
    Abstract:
    Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.
    [Abstract] [Full Text] [Related] [New Search]