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  • Title: Inhibition by AA861 of prostaglandin E2 production by activated peritoneal macrophages of rat.
    Author: Ohuchi K, Watanabe M, Taniguchi J, Tsurufuji S, Levine L.
    Journal: Prostaglandins Leukot Med; 1983 Oct; 12(2):175-7. PubMed ID: 6417676.
    Abstract:
    Prostaglandin E2 production by rat peritoneal activated macrophages was inhibited by AA861 which had been reported as a selective inhibitor of 5-lipoxygenase from guinea pig peritoneal leukocytes. At a dose of 3.06 microM, prostaglandin E2 production was decreased to 27% of control. No inhibition of the release of (3H)arachidonic acid from the prelabeled macrophages was observed at the dose.
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