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  • Title: Differences in morphology and protein pattern of human blood platelets during irreversible and diamide mediated reversible aggregation.
    Author: Hofmann B, Danz R, Hofmann J, Pescarmona G, Bosia A, Meyer M, Lösche W, Till U.
    Journal: Biomed Biochim Acta; 1983; 42(5):489-501. PubMed ID: 6418156.
    Abstract:
    Morphological alterations of platelets during reversible aggregation mediated by diamide are compared with those observed during irreversible aggregation. Diamide prevents cell fusion and the formation of loop-like structures which probably arise from fusing plasma membranes. Differences in the protein pattern of platelets after reversible and irreversible aggregation suggest a specific involvement of SH-proteins in irreversible platelet aggregation. The diamide mediated alterations of platelet aggregation behaviour are transitory, i.e. reversibly aggregated platelets respond normally to a new addition of aggregation inducers without and with diamide, respectively.
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